Brand name: Xeloda®
Manufacturer / Distributor:
Xeloda is available by
On June 2005,
Capecitabine (Xeloda) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of
certain colon cancers; other indications were subsequently approved.
Indication: Xeloda is used alone or in combination
with chemotherapy medications to treat:
III colon cancer after resection of the tumor
first-line treatment (first-line therapy)
or metastatic breast cancer, alone or in combination with docetaxel after failure of first line
Xeloda comes in tablet
form to take by mouth
Dosage: Basing on certain criteria such as
your age, medications you are taking, and your body surface area
(BSA), your oncologist will recommend the most effective xeloda dosage to combat the cancer. It is important
that you take the medication exactly as indicated in the prescription. Even if you experience side effects
during the therapy, do not stop or change the way you are recommended to take the medication. Modifying or
stopping the treatment without first contacting your doctor can lead to serious health problems.
Xeloda is taken in two equal doses twice daily, 12 hours apart for two weeks followed by a break period of one
week. Cycles can be repeated every three weeks until the end of the therapy. Do not crush the tablet; xeloda
should be swallowed whole with water within 30 minutes after a meal.
regular monitoring is very important during treatment with Xeloda. Therefore, it is important to respect all
appointments with your doctors and lab specialists; this allows them to perform cardiac examination,
neurological evaluation and blood tests to detect minor problems in their genesis before they become serious
Xeloda should be kept
tightly closed in the container it came, out of the reach of children. Keep the drug at room temperature (15-30 ° C),
away from heat above 40 ° C, light and moisture. Xeloda
and all other medications should not be used beyond the expiration date printed on the container.
Overdose: overdosing any chemotherapy drug can
lead to death. The risk of complications increases considerably when the drug is overdosed for long term. Even
in the absence of overdose, Xeloda can cause serious bleeding and death when used with anticoagulants such as
warfarin (Coumadin). Xeloda tends to damage the bone marrow, and lead to decreased blood cells
count. It is extremely important that you take Xeloda as
indicated by your physician or pharmacist; don’t ever take it more or more often.
misusing any drug can
be fatal; chance of complications is even higher when it comes to chemotherapy drugs. Take Xeloda exactly as
prescribed; taking less can decrease the therapeutic effects of the drug; taking more can lead to serious
health problems and even death. Do your best to take the medication around the same time every day.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is time or almost time for your next
do not double the next dose to recover the missed one. Contact your doctor or wait to go back to your regular
contraindicated or should be used with precaution in the following conditions:
or lactase deficiency
to xeloda or one of its components
- Glucose-galactose malabsorption
combination with sorivudine therapy or chemically related analogues, such as brivudine.
Mechanism of action (MOA): Xeloda is an antineoplastic; it kills
cancer cells by selectively inhibiting the synthesis of their DNA.
It is not recommended
to use Xeloda in combination with certain prescription and non prescription medicines. In addition, the
following drugs can alter the effects of xeloda, or increase the risk of side effects. Talk with your
oncologist before taking:
certain other anticancer drugs.
cells, Xeloda also affects normal cells, and cause adverse reactions in some patients. Common xeloda side
- mouth blistering
- dry mouth
- loss of appetit
- Dry or
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
or sever vomiting
- signs of
infections: chills, sore throat, fever chill, ect.
of face, fingers, feet or lower legs
or lack of coordination
blood pressure lowering or rising
pain, tingling or other unusual sensations in the palms
swelling or ulceration of the mouth
Blisters, redness, swelling or peeling of the skin in the hands or soles of feet.