Brand name: Oncovin®, Vincasar®
Other names: Vincristine Sulfate, leurocristine
Distributor: Eli Lilly and Company
Vincristine is available
by prescription only
Vincristine is used alone or in combination with other chemotherapy agents to treat a variety of
- small cell lung
and hodgkin's Lymphoma
sarcoma related to acquired immunodeficiency syndrome (AIDS).
Vincristine can be prescribed for
other health problems; talk to your physician or pharmacist for more information
form: Vincristine is given by injection into
to determine an
dosage, your physician will consider the type of cancer you have, your health status (presence of other diseases or
not), and your body surface area (height and weight). Depending on the response of your body to the drug, your
physician can change the dosage even after the therapy has started. Usually, lower doses are given to patients who
are taking other drugs, or undergoing
injected into a vein. The usual dose for adults is 1.4 mg/m2 body surface area. The injection is repeated once a
week throughout the duration of the therapy, if there is no complications. The drug may leak into surrounding
tissue; therefore, a close monitoring is necessary throughout the treatment.
general, Vincristine is administered under medical supervision in a hospital or health center with adequate
equipments for the preparation of the drug. Manipulating Vincristine requires caution, and must be done by an
oncologist or a health professional that has experience in chemotherapy drugs.
Vincristine is given in
hospital by professionals; the risk of overdose is virtually nonexistent; however, accidental overdose or
administrative mistake can happen. Vincristine overdose can damage your bone marrow, and cause a decrease in
the number of blood cells. Overdosing chemotherapy drugs can cause death or severe health problems.
Sometimes, Vincristine can cause
urinary tract infections, especially in the treatment of acute leukemias. To reduce or prevent urinary problems
during treatment, you can drink plenty of fluids. After talking to your doctor about it, you can also drink
Vichy water or Carbonated Water.
fact that Vincristine is administered in hospital, missing dose
is basically difficult if you keep your doctor’s appointment. Therefore, be present at each appointment to take
every dose of Vincristine prescribed by your doctor. If for some reason you cannot go to the hospital for the
treatment, contact your oncologist before the date schedule for the injection.
taking Vincristine requires regular blood monitoring. Vincristine is contraindicated in the following
to Vincristine or one of its components
- if you are of childbearing age, an effective contraception during treatment can be applied to prevent
against yellow fever, live attenuated vaccines, phenytoin, fosphenytoin and itraconazole.
Mechanism of action (MOA): Vincristine belongs to a class of
chemotherapy drugs known as vinca alkaloids; it slows or stops multiplication of cancer cells by interfering
with their genetic material (DNA).
tell you to your doctor before taking prescription or non prescription medication such as aspirin, vitamins,
nutritional supplements, and St. John's wort. Some medicines may interact with Vincristine; tell your doctor or
pharmacist if you are taking any of these medications:
other cancer drugs
In addition to attack
cells, Vincristine may interfere with certain normal cells, causing a number of side effects:
pain and cramps
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
throat and fever (which can indicate infection)
numbness, and cramping in the legs or arms
abdominal or muscle cramping
diarrhea or constipation
of the feet and ankles
urination or urgent need to urinate
pain, or swelling at the injection site.