is classified as an "topoisomerase 1 inhibitor
Topotecan is available
by prescription only
Indications: Topotecan is used to treat:
cancer after failure of first
line or subsequent chemotherapy
cell lung cancer that has relapsed or metastasized after treatment with other chemotherapy
Topotecan may also be prescribed for
other medical conditions besides ovarian and small cell lung cancer; talk to your doctor or pharmacist for more
information on Topotecan.
Topotecan is given by
injection into a vein
Dosage: in general, your oncologist will
consider your condition, the type and severity of the cancer, and your body mass index to prescribe you an
effective dosage of Topotecan. If you are taking other chemotherapy drugs, it may also play a role in the choice
of the dosage. Usually, Topotecan is injected into a vein over 30 minutes. The drug is given once a day for 5
consecutive days, and then suspended for 16 days. The cycle is then repeated at least 3 times.
Depending on your body's reaction to
the medication, your oncologist may change the dosage. It is important to undergo the therapy completely.
Topotecan should be administered with great care by oncologist or medical professional that have experience in
chemotherapy drugs. In addition, Topotecan must be given in a hospital or a similar institution that has enough
equipment for its preparation.
Overdose: Topotecan overdose can cause decreased
levels of white blood cells in the blood, which can be dangerous in fragile patients. Although rare, an overdose
of Topotecan may also lead to kidney problems. If you think you have been given an overdose or you experience
abnormal symptoms, contact your doctor immediately.
the fact that Topotecan
is administered in hospital, missing dose is basically difficult if you respect your doctor’s appointments.
Therefore, If for some reasons you cannot go to the hospital for the treatment, contact your oncologist
before the date you are scheduled for the injection. Do not stay
home because you are experience side effects; Topotecan
cause side effects in most patients. Missing a session of the therapy can
affect the entire treatment.
not be to take Topotecan if you have :
- low number of white
production of platelets
to Topotecan or any of its ingredients
- severe liver failure.
Mechanism of action (MOA): Topotecan belongs to the class of
chemotherapeutic drugs known as topoisomerase type 1 inhibitor. Normally, before a cell divides into two, its
DNA is copied and each daughter cell receives a copy. Topotecan slows or stops growth of cancer cells by
interfering with their DNA material needed for reproduction.
Interactions: talk you to your doctor before
prescription or non prescription medications.
Some medicines may affect the therapeutic effects of Topotecan, or increase the risk of developing side effects.
Tell your doctor and pharmacist if you are taking any of these medications:
- All other chemotherapy
Side effects: while attacking
cells, Topotecan also affects
healthy cells, which lead to, in certain patients, the following side effects:
- difficulty sleeping
- skin rash
- mouth sores
- stomach or back pain
- nausea and
- runny nose
- fatigue or
- Unusual fever or
chills accompanied by cough or hoarseness.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
bleeding or bruising
- fast or
tingling, or burning sensation in the hands or feet
problems: hives, rash, itching, etc.
breathing or swallowing
Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs.