Brand name: Sutent®
Other names: SU11248
inhibitor (receptor protein-tyrosine kinase inhibitor)
Manufacturer / Distributor:
Sutent is available by
In January 2006, Sutent (Sunitinib)
was approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced renal cell
carcinoma (RCC) and gastrointestinal stromal tumors (GIST).
: Sutent is mainly used to treat:
cancer that has spread to other parts of the body;
stromal tumors [rare forms of gastrointestinal (GI) tract cancers] in patients who cannot be or were
treated unsuccessfully with imatinib (Gleevec).
In addition to these
conditions above, Sutent can be used to treat other medical conditions not mentioned in the article; ask your
doctor or pharmacist for more information.
Sutent is available in
capsule form to be taken by mouth
Dosage: usually, Sutent is prescribed by an oncologist or physician that has experience
in chemotherapy drugs. Basing on your condition, age and body surface
area (BSA), your physician will determine the most effective dosage to combat the disease. Take the
medication exactly as directed by your doctor, pharmacist or according to the directions on the prescription.
Misusing Sutent may not only affect its curative effect but also cause serious health problems.
Usually, the recommended dose is 50 mg, taken by mouth once daily for 4 weeks; each dosing cycle is followed by a
2-week break. Sutent
can be taken with or without food; however, it is recommended to take it around the same time every day. Do not
open, chew or crush the capsules; swallow each capsule whole. If you experience adverse effects, do not change or
stop taking the medication without first consulting your doctor.
Storage: keep Sutent tightly closed in the
container it came, out of the reach of
children. Store it
at room temperature, away from heat, light and moisture. Sutent
and all other medications should not be used beyond the expiration date printed on the container.
Overdose: chemotherapy drugs are strong;
overdosing any of them can be fatal. The risk is even higher
when the drug is overdosed for a long period of time. In fact, overdosing of certain chemotherapy drugs,
including Sutent, can lead to death. Even in the absence of overdose, Sutent tend to affect the bone marrow, and
lead to decreased blood cells count. It is extremely important that
you take Sutent as indicated by your physician or pharmacist; don’t ever take more.
do your best to take
the drug around the same time every day; do not miss or take less of it.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
contraindicated or should be used with precaution in the following conditions:
to Sutent or one of its components
of heart failure
- port of
of heart failure or stroke
Mechanism of action (MOA):
Sutent is an inhibitor of tyrosine kinase; it acts by blocking the action of
tyrosine kinases, abnormal protein that signals cancer
cells to multiply.
if you are
taking sutent, it is not safe to eat or take grapefruit, aspirin, vitamins, nutritional supplements, or St. John's wort without first
contacting your doctor.
Some substances may interact with sutent, and increase the risk of side effects; tell your doctor or pharmacist if
you are taking any of these medications:
- diltiazem (Cardizem,
Dilacor, Tiazac...) verapamil (Calan, Isoptin,
procainamide (Procanbid, Pronestyl)
sotalol (Betapace, Betapace
(Carbatrol, Equetro...) phenobarbital
- phenytoin (Dilantin,
- thioridazine (Mellaril).
In addition to attacking
cells, sutent also interfere with certain normal cells, leading to the development of number of adverse effects.
Most common Sutent side effects include:
- sores on
your lips or mouth
or limb pain
burning, numbness, or tingling in the hands or feet.
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
- signs of
infection: fever, sore throat, chills, etc.
irregular, or pounding heartbeat
bruising or bleeding
and tarry stools
- blood in
stools or/and urine
pain or swelling
of your feet or ankles
tenderness, warmth, or redness of a leg
of breath or difficulty breathing
falling asleep or staying asleep
up bloody mucus.