Brand name: Sprycel®
Manufacturer / Distributor:
Sprycel is available by
U.S. Food and Drug Administration (FDA) approved Sprycel in 2006 for the treatment of certain types of
cancers (see indications)
is used to treat the following cancerous
in case of resistance or intolerance to prior therapy;
chromosome-positive acute lymphoblastic leukemia (Ph + ALL) in adults, in case of resistance or intolerance
to prior therapy.
is sometimes used to treat other medical conditions not mentioned in this article; talk to your physician or
pharmacist for more information.
Sprycel is available in
tablet form to be taken by mouth
Dosage: to choose the most effective dosage to
combat the disease, your physician will rely on several factors: age, health status, body surface area (BSA), type and severity of the
cancer. Usually, lower doses are
given to patients that are taking other drugs. Misusing Sprycel can cause serious health problems; it should be
prescribed by an oncologist or physician trained or experienced in the use of chemotherapy drugs.
Do not change or stop taking the medication even if you
experience side effects; chemotherapy drugs – including Sprycel - cause side effects in most
Sprycel is taken 2 times daily, 1 tablet in the morning and 1 tablet in the evening, with or without food. It is
better to take the medicine around the same times every day. SPRYCEL should be swallow whole, do not chew or
crush the tablet. In addition, avoid drinking grapefruit juice or eating foods rich in fat during the
Sprycel exactly as directed by your doctor is very important. If for valid reasons (such as development of major
complications) you cannot continue the therapy, contact your physician immediately; do not discontinue the
treatment without first contacting your doctor.
Storage: keep Sprycel tightly closed in the
container it came, out of the reach of
Sprycel at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Sprycel and all other
medications should not be used beyond the expiration date printed on the container.
Overdose: any chemotherapy drug overdose can be
fatal. The risk of complication is even higher when the drug is overdosed for a long term. In fact, overdosing
of certain chemotherapy drugs, including
Sprycel, can lead to
death. Even in the absence of overdose,
Sprycel can damage the
bone marrow. It is extremely important that you take the medication as
indicated by your health care provider or according to the directions on the label.
do your best to take
the medication around the same time every day.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one. Contact your doctor or wait to go back to your regular
is contraindicated in case of:
to the drug or any of the constituents
Mechanism of action (MOA): Sprycel is a protein-tyrosine kinase
inhibitor. That is, it works by blocking the protein kinases, proteins that are located within the leukemic
cells, and are responsible for their uncontrolled proliferation.
Interactions: if you are taking sprycel, it is better to talk to your doctor before taking aspirin,
vitamins, nutritional supplements, or St. John's wort. Certain substances can
interact with sprycel, et cause health problems. Common drugs that tend to produce interaction with sprycel
(Coumadin) daunorubicin (Cerubidine)
(Biaxin) dexamethasone (Decadron)
- erythromycin (Erythrocin) f
Actiq) atazanavir (Reyataz)
(Crixivan) nelfinavir (Viracept)
(Cordarone) disopyramide (Norpace)
(Tambocor) mexiletine (Mexitil)
(Rythmol) quinidine (Quinidex)
(Tonocard) cimetidine (Tagamet®)
(Prevacid) omeprazole (Prilosec)
(AcipHex) carbamazepine (Tegretol)
- phenobarbital (Luminal) phenytoin
(Dilantin) moxifloxacin (Avelox)
- nefazodone; pimozide
(Rimactane) simvastatin (Zocor)
- telithromycin (Ketek) procainamide (Procanbid,
In addition to attacking
may interfere with certain normal cells, and lead to the development of side effects in some patients; most common
side effects include:
- loss of
pain or pain in your hands or the feet
sores or swelling and pain inside your mouth
pain or swelling.
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
- signs of
infections: fever, sore throat, chills, ...
of the eyes, hands, arms, feet, ankles or lower legs
of breath or difficulty breathing
up bloody mucus
chest pain or chest pressure
- rapid or
bruising or bleeding
and tarry stools
- blood in
stools or urine
- slow or
or numbness of an arm or leg.