Paclitaxel (Taxol, Onxal)
Brand name: Taxol ®,
alkaloid, taxane and antimicrotubule agent
Paclitaxel is available by prescription only
Paclitaxel (Taxol, Onxal
) was approved by
the US Food and Drug Administration (FDA) to treat metastatic
Paclitaxel is used to treat the following cancers:
- head and neck
- lung cancer: non-small
cell lung cancer and small cell lung cancer
- melanoma (dangerous
form of skin cancer)
- Esophageal cancer (
cancer of the Esophagus).
Paclitaxel is sometimes used to treat other medical conditions; talk to your physician or pharmacist for more
Paclitaxel is given by
injection into a vein
Basing on certain criteria such as your age, type of cancer being treated, and your body surface
, your physician will prescribe you the most effective dose to combat the disease. Even after you start the
treatment, your doctor may change the dosage depending on the response of your body to the medication.
paclitaxel is injected into a vein (intravenous injection) by an oncologist or health care professional
qualified and has experience in giving chemotherapy drugs. The drug should be administered in a hospital or
health center equipped for its preparation. Paclitaxel is usually given once every 3 weeks over 3 hours.
Overdose: paclitaxel is given in hospital by
professionals; the risk of overdose is very difficult, but not impossible. Paclitaxel overdose may cause a
decrease in the number of blood cells in your bone marrow, and lead to severe health problems and even death.
Keep all appointments with your doctor before, during, and after treatment with paclitaxel; regular checkups can
help detect abnormalities in early stage before they become serious health problems.
the fact that
paclitaxel is administered in hospital, it is difficult to miss a dose if you keep your doctor’s
appointments. Therefore, be present at each appointment to take all doses of paclitaxel prescribed by your
doctor. Misusing any chemotherapy drug can be fatal. If for some reasons you cannot be present for the
treatment, contact your oncologist before the date of the treatment.
Paclitaxel or is not recommended under the following conditions:
paclitaxel or one of its components
polyethoxylated castor oil.
Mechanism of action (MOA): Paclitaxel belongs to antineoplastics,
a class of chemotherapy drugs that works by stabilizing the mitotic spindle (also called nuclear spindle, formation of protein fibers in the cytoplasm of a cell during cell
division), which slows or stops the growth of cancer cells.
Interactions: if you are taking Paclitaxel, tell
your doctor before taking prescription or non prescription medications such as aspirin,
vitamins, nutritional supplements, and St. John's wort.
Some medicines may interact with Paclitaxel and causes health problems. Tell your doctor or pharmacist if you
are taking any of these medications:
In addition to attacking
cells, Paclitaxel may interfere with certain normal cells, causing a number of side effects in most
- hair loss
- nausea and
- loss of
or/and skin discoloration
in the hands or toes
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
diarrhea or constipation
bruising or bleeding
redness, or swelling at the injection site
signs: skin rash, fever, chills, cough, sore throat, etc.