Brand name: Nolvadex ®
Manufacturer / Distributor:
Nolvadex is available
by prescription only
citrate) was approved by the U.S. Food and Drug Administration (FDA) in October 1998 for the treatment of
certain breast cancers in men and women.
Indications : Nolvadex is an antiestrogen; it is used to treat certain
forms of breast cancer in men and women, mainly:
breast cancer that has spread to other parts of the body;
is used as a preventive treatment in people who are at high risk for developing breast cancer. Nolvadex is also
used to prevent complication in women who have had ductal carcinoma in situ (DCIS).
is sometimes prescribed to treat ovulation problems in women who want to get pregnant but are unable to produce
eggs. In addition, the medication can be used in the treatment of McCune-Albright syndrome, a genetic disease
that affects the bones and color (pigmentation) of the skin in children.
Nolvadex comes as white
coated tablet to be taken by mouth
to prescribe you an effective dosage of nolvadex, many criteria will be taken in considerations: your age, health
status, and your body surface area (BSA). In addition, taking other
medications as well as the severity of the cancer can play a role in the choice of the treatment. Having this
information, your oncologist will recommend you an effective dosage able to combat the disease.
Follow the indications
of your health care provider or the directions on the prescription label carefully.
the recommended daily dosage of
nolvadex is 20 to 40
mg in single or multiple doses, before, with or after meals. In the case of adjuvant therapy, the recommended dose
is 20 mg per day, for a period of 5 years. In the treatment of advanced cancer, daily doses are between 20 and 40
mg, taken once or twice a day. Do not take less or more of the medication.
water, natural juice or any non-alcoholic drink to swallow nolvadex tablets; do not chew or crush them. It is
better to take nolvadex around the same time every day. It is very important that you take the pills as directed
by your physician or pharmacist. Do not change the prescribed dosage or interrupt the treatment without first
talking to your doctor.
Storage: keep nolvadex tightly closed in the
container it came, out of the reach of
children. Store it at room temperature (15-25
° C), away from heat, light and moisture. Nolvadex and all other drugs should not be used beyond the expiration
date printed on the container.
Overdose: nolvadex overdose can be fatal. The
risk is even higher when the drug is overdosed for a long term. In fact, most chemotherapy drugs overdose,
including nolvadex, can lead to death. Even in the absence of overdose, nolvadex can cause strokes, blood clots
in the lungs, and cancer of the uterus. It is extremely important that you take nolvadex as indicated by your
health care provider or according to the directions on the label.
do your best to take
nolvadex around the same time every day.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule. Misusing nolvadex can cause life threatening
is contraindicated in the following conditions:
who are breast-feeding
(unless under strict medical supervision).
during the therapy, it is
important that you keep all appointments with your doctor and laboratory for regular medical examinations,
especially cardiologic and gynecologic exams. Regular checkups help your physician to detect early signs of
cancer of the uterus or/and heart problems related to Nolvadex.
Mechanism of action (MOA): Nolvadex is an antiestrogen; it slows
or stops the multiplication of cancer cells by blocking the hormonal effects of estrogen in the body.
talk to your doctor before taking prescriptions and non-prescription substances such as aspirin, vitamins,
nutritional supplements, and St. John's Wort. Some medicines may interact with Nolvadex. Tell your doctor and
pharmacist if you are taking any of these medications:
- Bupropion (Wellbutrin,
- Doxorubicin (Doxil,
- Methadone (Dolophine,
- Phenytoin (Dilantin,
- Rifampin (Rifadin,
Side effects: Nolvadex not only attack
cells but also healthy
cells, which often leads to adverse reactions in most patients. common Nolvadex side effects
- hair loss
- tumor pain
- nausea and
- headache and
- stomach pain or
- loss of sexual desire
or ability (in men)
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
1 - encyclopedia.com, document
2 - nlm.nih.gov, Nolvadex