Brand name: Navelbine ®
Other names: Vinorelbine Tartrate
Manufacturer / Distributor:
Navelbine is available
by prescription only
Indications : Navelbine is used to treat many
cell lung cancer
- metastatic breast
Navelbine can be prescribed for other
medical conditions not listed in this article; contact your doctor or pharmacist for more
Navelbine is given by injection into a vein
Dosage: Your oncologist will consider several
criteria to prescribe your an appropriate dosage: your age, body surface area (height and weight), type of
cancer treated, taking other medications or not, as well as your health status. Usually, a lower dose of
Navelbine is recommended when it is taken in combination with other drugs or therapy (
therapy for instance). Depending on your body’s
reaction to the drug, your doctor may stop or change the way you take it.
Navelbine is injected into a vein. Navelbine can be used alone or in combination with other chemotherapy
medications. The usual dose is 25-30 mg/m2 body surface, once a week. To avoid endovenous irritation, your
doctor may dilute the drug in normal saline, and infuse it in 20 minutes, following by a rinsing of the vein. In
general, the drug is given in a hospital or health center with sterilization equipment for its preparation.
Navelbine should be administered by your oncologist or a physician experienced in chemotherapy drugs.
Overdose: overdosing any chemotherapy drug is
dangerous. Overdose of Navelbine can lead to a decrease in white
blood cells and platelets, which can cause serious infections. Even in the absence of overdose, Navelbine can
cause neurological problems, which can be characterized by an abolition of tendon reflexes and impaired
sensitivity to the limbs. Navelbine can also cause broncho-pulmonary and heart problems.
the treatment, keep all appointments with your doctor and laboratory. Contact your doctor or the poison control
center nearest you immediately if you experience these symptoms: loss of muscle coordination, vision and/or
speech problems, sore throat, persistent cough, frequent or painful urination.
is given in hospital; it is basically difficult for you to miss any dose if you are present in the hospital for the
treatment. Therefore, it is very important to keep all appointments with your
. If for some reasons you cannot go to the hospital, contact your oncologist before the date scheduled for the
therapy. Do not
stay home because you experience adverse effects; Navelbine causes side effects in most
Contraindication: Navelbine is contraindicated or should be used with
precaution in the following conditions:
any of its ingredients
white blood cell count and/or platelets
who are pregnant or breastfeeding.
Mechanism of action (MOA): Navelbine belongs to the plant alkaloids; it slows or stops the progression of
cells by interfering with their genetic material (DNA), an element essential for their reproduction.
Interactions: talk you to your doctor before taking
aspirin, vitamins, nutritional supplements, or any non prescription medication. Certain medications can interact
with Navelbine. Tell your doctor or pharmacist if you are taking any prescription medication, especially
cisplatin (Platinol), mitomycin (Mutamycin), and other chemotherapeutic drugs.
Side effects: a
s with any chemotherapy drugs, Navelbine
cause side effects in most patients. most common Navelbine side effects include
- hair loss
- increased risk of infections
or tingling in hands or feet.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
burning and tingling
bleeding or bruising
- sore throat or mouth
pain, or swelling at the site of the injection.