Brand name: Lysodren®
Manufacturer / Distributor:
Mitotane is available
by prescription only
Indications: Mitotane is used to treat adrenal
(cancer of the adrenal glands).
may also be prescribed for other medical conditions besides cancer of the adrenal gland; contact your doctor or
pharmacist for more information.
Mitotane comes as
to be taken by
Dosage: Mitotane is taken by mouth, usually 3
or 4 times daily with or without food, around the same times every day. At the beginning of the therapy, the drug can be given in hospital starting
with small doses until a stable dosage is established. Once the most effective and appropriate dosage is
determined, you will take the drug at home as directed by your oncologist or pharmacist. It is important that
you follow the instructions carefully.
physician will determine the dosage based on your medical condition(s), other medications you are taking, your
body surface area (BSA) and the response of your body to the treatment. Depending on the reaction of your body to the drug, your doctor may reduce or
increase the dosage. The fact you develop side effects it does not mean complications; Mitotane cause adverse
reactions in most patients.
Storage: store Mitotane
at room temperature (15-25 ° C), away from heat, light and moisture. Always keep your medications out of the reach of children
and all drugs should not be used beyond the expiration date printed on the container.
Overdose: it is very important that you
Mitotane as indicated by your health care provider. Regardless of the circumstance, do not take Mitotane more often. Even when
taken at normal dose
, Mitotane can reduce the amount of steroid hormones (cortisol) synthesized by the adrenal cortex, which can lead
to the development of life-threatening conditions. If you think you have taken an overdose, contact your doctor or
the poison control center nearest you as soon as possible.
Mitotane as indicated your doctor or pharmacist.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
Mitotane is contraindicated in cases of allergy to it or any of its ingredients. Before beginning a treatment with
Mitotane, tell your doctor if you are:
Mechanism of action (MOA): Mitotane is an antineoplastic agent
that works by reducing the amount of steroid hormones synthesized by the adrenal cortex, which slows or stops
division or reproduction of
cells that need these hormones to survive.
Interactions: talk you to your doctor before taking
vitamins, nutritional supplements or St. John wort. Certain medications may interact with
Mitotane. Tell your doctor or pharmacist if you are taking any of these medications:
such as warfarin (Coumadin)
anxiety, mental illness, or seizures.
Side effects: in certain
patients, Mitotane can lead to
- lack of
- Rash or changes in
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
- fast or
or side pain
fever or shaking chills
sweating, mainly at night
blue, or black discoloration of the skin.