Generic name: Mitomycin
Other names: Ametycine,
Therapeutic Class: Antibiotics, Antineoplastic, Alkylating
Agents, Cross-Linking Reagents, Nucleic Acid Synthesis Inhibitors
Manufacturer / Distributor: Sanofi-aventis
Mitomycin is available by
Indications: Mitomycin is used in the treatment of many malignancies,
cell carcinoma (
cancer) of the head and neck,
lungs, and cervix
(cancer) of the stomach, pancreas, colon, rectum, breast and their metastases
physician can use Mitomycin
to treat other types of cancer if they believe it may be helpful.
form: Mitomycin is given by injection into a
In general, Mitomycin
is taken by intravenous injection. Placement of a catheter or implantable port is often necessary. You can
take Mitomycin either in hospital or at home by a nurse well trained to administer chemotherapy medications.
However, it is important that Mitomycin be administered carefully under supervision of a physician who has
experience in chemotherapy drugs. Mitomycin must be administered very carefully.
dosage varies from one patient to another; to determine an effective Mitomycin dosage, your doctor will consider
your body surface area (calculated from your height and weight), type of cancer being treated and its location
as well as its severity (metastatic or not). If Mitomycin is taken
in combination with other drugs or therapies (mainly
therapy), the doses can be decreased.
Mitomycin is usually injected into a
vein, but it can also be administered intravesically (into the bladder) for treatment of bladder tumor. If you
receive the medicine intravesically, it is recommended not to drink liquids 12 hours before the intervention.
The solution usually remains in the bladder for two hours.
Overdose: as with any drug, Mitomycin overdose
can be dangerous. An overdose of Mitomycin can damage the bone marrow, and cause serious kidney damage. In fact,
even at normal dose, Mitomycin can cause serious urinary side effects. To reduce risk of kidney damage and side
effects, drink plenty of fluids during the therapy, and keep all appointments with your doctor.
is administered in hospital, it is basically difficult for you to miss any dose if you present for the treatment.
Therefore, it is very important to keep all appointments with your
. If for some reasons you cannot go to the hospital for the treatment, contact your oncologist before the date
scheduled for the injection.
contraindicated in the following conditions:
- allergy to Mitomycin
or any of its components
Mitomycin is not recommended in combination with vaccine against yellow fever, and
- Pregnancy – Mitomycin
is contraindicated during pregnancy because it is mutagenic effect; it can cause malformations in the
fetus. Therefore, before beginning the therapy, talk to your doctor about a reliable birth control method
to prevent pregnancy if you are sexually active.
chemotherapy drugs affect your entire body. Some molecules of Mitomycin can be toxic to the infant;
therefore it is not recommended to breast-feed during treatment with
Before taking any
prescription and/or nonprescription medication, talk to your doctor; taking nutritional supplements or vitamins
without approval of your physician is not recommended.
The following drugs can alter the curative effects of Mitomycin, or increase the risk of developing side
other chemotherapy drugs, particularly anthracyclines.
Mechanism of action
(MOA): Mitomycin is an antibiotic; it slows
or stops the growth of cancer cells by altering the structure of their DNA, which prevents them from
Side effects –
Mitomycin attack not only
cells but healthy cells that multiply quickly, which often leads to adverse effects; the most common Mitomycin
side effects include:
- loss of
blistering or stomatitis - inflammation of the mucous lining of any of the
structures in the mouth
may also cause elevated liver enzymes in the blood, absence of periods (amenorrhea) and azoospermia (no
sperm in semen in the
doctor immediately if you experience any of the following medical conditions:
bruising or bleeding
or difficulty urination
of the ankles or feet
redness, or swelling at the injection site
breathing or shortness of breath
Signs of infection: fever, chills, sore throat, itching or rash.