names: L-PAM, L-Sarcolysin,
form: Melphalan can be taken by intravenous
injection (IV) and/or as tablets by mouth, on an empty stomach.
is classified as a nitrogen mustard alkylating agent
Disponibilty: Melphalan is
available by prescription only
Melphalan is used in the
- malignant melanoma
Breast cancer - in advanced stages or in addition to surgical
Occasionally, Melphalan is used to treat the following cancers:
- chronic myelogenous leukemia, one
of four main types of leukemia
- Osteogenic sarcoma, one of the
most common forms of bone cancer in children.
Note: your doctor can use the drug to
treat other medical conditions non-mentioned in this article if he believes it can be helpful.
contraindicated in the following conditions:
- allergy to Melphalan or one of
- breastfeeding is not recommended
while taking Alkeran
- using Melphalan is
not recommended during pregnancy, especially during the first quarter; the drug may cause problems which
can be harmful to the fetus
- Elderly, infants and children are
treated with Melphalan under strict medical supervision.
have one of the following medical conditions, let it be known to your doctor before beginning an Melphalan
- glucose-galactose malabsorption
- You have
been treated with radiation
therapy or antineoplastic agents during the previous 3 weeks.
Mechanism of Action
Melphalan destroys cancer cells by forming cross-linkages between DNA strands (deoxyribonucleic acid), which
thereby inhibiting the replication of tumor cells.
: Melphalan may be toxic or cause serious infections when it is associated with nalidixic
, cyclosporine or other immunosuppressants. In addition, the association of high-dose Melphalan and cyclosporine is
toxic to the kidney.
: Melphalan attack not only
cells but healthy cells that multiply quickly, which often leads to adverse effects. The most common Melphalan
side effects include:
- loss of
- weight loss
- rash and
- increased risk of
- Pulmonary fibrosis
- Mouth blistering,
sometimes inflammation of the mouth.
doctor immediately if you experience any of the following symptoms:
black, tarry stools
urine or blood in
of the skin or eyes
- increased risk of infection
Difficulty breathing or shortness of breath .