Brand name: Megace, Megace
Other names: Megestrol Acetate
Manufacturer / Distributor:
Megace is available by prescription only
Indications: Megace is
used to treat the following cancers:
- advanced breast cancer
- Advanced endometrial
cancer (also called uterine
is also used to treat malnutrition, loss of appetite and weight loss in patients with AIDS. That is, by using
Megace, you can have your appetite and weight increased.
Megace comes as a
tablet, a suspension (liquid) and a concentrated suspension (called Megace ES) to take by
Dosage: to prescribe a dose of Megace which is
able to fight your disease, your doctor will consider the type of medical condition you have, your health status
(presence of other diseases or not), and your body surface area (BSA). If you are taking other medication (s),
you can be prescribed a lower dosage of Megace.
case of breast cancer, your oncologist may recommend you to take three or four doses of 40 mg of Megace daily
with or without food; usually the maximum dose is 160 mg per day. For cancer of the endometrium, the usual dose
is 80 to 320 mg per day, which can be divided into doses of 40 to 80 mg administered 1-4 times per day; or one
or two 160 mg tablet per day with or without food. Usually, the recommended dose in the treatment of
cancer is a single dose of 120 mg daily, combined with diethylstilbestrol. It is important that you take the
medication around the same time every day.
cases, your doctor can indicate different doses. It is necessary that you follow the indications exactly
throughout the treatment. If you experience serious side effects or complications, contact your doctor
immediately. Do not change or stop taking the medication without
first consulting your doctor.
shake the liquid well before using it.
your doctor or pharmacist for information on the use of Megace in the treatment of acquired immunodeficiency
Storage: store Megace at room temperature, away
from direct sunlight, moisture and heat above 40 ° C. Keep Megace out of the reach of children. Do not store Megace and all medications in the bathroom. Megace and all other medications
should not be used beyond the expiration date printed on the container.
Overdose: Do not take Megace more often than
prescribed by your doctor. As with any drug, persistent overdose can be dangerous. If you think you
have taken an overdose of Megace, contact your doctor or a poison control center near you as soon as possible.
do your best to take
Megace as indicated by your doctor or pharmacist.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
contraindicated or should be used with precautions in case of the following conditions:
- hepatic porphyria (liver
- allergy to Megace or one of its
- glucose galactose
- Congenital lactase deficiency.
doctor is you have a history of stroke, diabetes, kidney or liver disease, and blood clot.
Mechanism of action (MOA): Megace is a progesterone; it slows or
stops the multiplication of cancer cells in the
by inhibiting the production of testosterone in the body. In the treatment of breast or endometrial cancer,
Megace interfering with other hormones and proteins necessary for the division of the
Interactions: talk you to your doctor before taking
vitamins, nutritional supplements or St. John wort.
Some medications can interact with Megace
. Tell your doctor and pharmacist if you are taking any medication.
Side effects: in certain
patients, Megace can lead to
- increased blood
- rapid or unusual
- gas or
- decreased sexual
- unexpected vaginal
- lack of
- breast tenderness or
- Appearance of brown
spots on exposed skin.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
- fast or irregular
- excessive sweating,
mainly at night
- purple, blue, or black
discoloration of the skin
- chest pain or
heaviness in chest
- weakness or numbness
of an arm or leg
- pain or swelling in
Swelling of face, ankles or feet.