Brand name: CeeNU
Other names: CCNU
Distributor: OTL Pharma
Lomustine is available by
Lomustine is used to treat
the following malignancies :
· hodgkin's Lymphoma
· non hodgkin's Lymphoma
cancers of the gastrointestinal
secondary brain tumors.
Lomustine is sometimes used in the treatment of non cancerous medical conditions such
as mycosis fungoides and psoriasis. Ask your
doctor or pharmacist for more information on the drug.
Dosage form: Lomustine comes in capsule form to be
taken by mouth
usually, the recommended doses of lomustine are 100 to 130 mg/m2 every 6 weeks, in monochemotherapy; and 70 mg/m2
every 3 weeks in polychemotherapy.
keep lomustine at room temperature (15-25 ° C), away from light, moisture and heat above 40 ° C. Lomustine and all
other medications should not be used beyond the expiration date printed on the container. Keep all medicines, including
lomustine, out of
Lomustine overdose is dangerous primarily because of its profound and long term myelotoxicity (state of
to bone marrow)
. An overdose of Lomustine can lead to decrease in white blood cells and/or platelets (decreased to 50,000 and
less), which can become life serious health problems 4 to 5 weeks after initiation of the treatment. If you believe
you have taken an overdose, contact your doctor immediately.
in case you missed taking the medication at the recommended time, you can take the medication right away; do not
double the next dose to recover the missed one, it can be dangerous. In fact, Lomustine is usually taken once every 3 or
6 weeks; you have no reason to double the dose.
: Lomustine is
contraindicated in these conditions:
allergy to Lomustine or has one of
A blood count with WBC inferior to
4000/mm ³ or has less than 100,000 platelets / mm³.
Mechanism of action (MOA): Lomustine slows or stops the growth of
cells in your body by attacking their DNA.
should not be associated with cyclosporine and tacrolimus due to a significant risk of Immunosuppression
(reduction of the
activation or efficacy of the immune system)
and lymphoma. Patients who are treated with Lomustine should not take live attenuated vaccine.
espite the beneficial effects of lomustine in combating cancer, it can damage non-cancerous cells, and lead to the
development of adverse effects; the most common Lomustine side effects include:
and dry skin
Lomustine can also cause
serious side effects which require immediate medical attention; contact your doctor immediately if you experience
any of these symptoms:
- red or
throat and fever
bruising or bleeding
of the skin or eyes (jaundice)
Shortness of breath or difficulty breathing.