Ifosfamide (Ifex, Mitoxana, Isophosphamide)
Brand name: Ifex
Other names: Mitoxana
Ifosfamide is available by
Indications: Ifosfamide is used in the treatment of a variety of cancers,
sarcoma (also called
(Hodgkin's and Non-Hodgkin's).
Ifosfamide can also be prescribed for
other medical conditions not mentioned in this article; talk to your doctor or pharmacist for more information.
form: Ifosfamide is given by injection into
recommending an appropriate dosage of Ifosfamide, your doctor will consider several factors, mainly your
health, taking other drugs or not, your body masses index and the type and severity of cancer.
general, Ifosfamide is given intravenously (into a vein), once a day for five days a week. The injection often
last at least 30 minutes. The treatment is then repeated every three or four weeks until the full therapy is
complete. Depending on your body reaction to the drug, your oncologist may change the way you are taking
Ifosfamide, which makes the length of treatment can vary from one patient to another.
Throughout the therapy and even months
after, it is important that you keep all appointments with your doctor. Ifosfamide can cause serious urinary
side effects and even death in fragile patients. Ifosfamide should
be administered with care by health professionals. The drug should also be given in a hospital or a medical
center that has sterilization equipments needed for its preparation.
Ifosfamide is eliminated by your
bladder and kidneys. Therefore, it is important that you drink plenty of fluids every day during the treatment;
8 to 12 cups of water per day are recommended. Do your best to urinate every two hours throughout the period of
wakefulness and at least once during the night; this is important to prevent damage to the bladder and kidneys.
If you still develop kidney problems, contact your physician so that he can prescribe you Mesna, a drug used to
reduce side effects of cancer chemotherapy involving cyclophosphamide and ifosfamide.
Overdose: as with any drug, ifosfamide overdose
can be dangerous. An overdose of ifosfamide can damage the bone marrow, leading to cause serious urinary
problems or death. In fact, even at normal doses, ifosfamide can cause serious urinary side effects. During the
treatment, drink plenty of fluids; keep all appointments with your doctor.
because Ifosfamide is administered in hospital, it is basically difficult for you to miss any dose if you present
for the treatment. Therefore, it is very important to keep all appointments with your
. If for some reasons you cannot be present at the hospital for the therapy, contact your oncologist before the
date scheduled for the injection.
Ifosfamide is contraindicated or should be used with precaution in the following
number of white blood cells
- decreased platelet
of urinary tract
to Ifosfamide or one of its ingredients
cerebral arteriosclerosis (hardening of the arteries of the brain).
Mechanism of action (MOA):
Ifosfamide belongs to the class of alkylating agents; it slows or stops the growth of cancer cells by attacking
their DNA, a material essential for the reproduction of cells.
talk you to your doctor
before taking aspirin,
vitamins, nutritional supplements, or any prescription medication. Certain
medicines may interact with Ifosfamide. Tell your doctor or pharmacist if you
are taking any of these medications:
- Interferons (Actimmune, Avonex, Betaseron, Rebif, and others)
- Aids/HIV medications
such as didanosine (Videx) and stavudine (Zerit)
- Live vaccins vivants
- Ganciclovir, an antiviral drug
- Azathioprine, an immune system inhibitor
depressant drug that causes relaxation
, a drug
used to inhibit the
production of acid in the stomach
medication used to treat pain of gouty arthritis
(Cytoxan), a medication of the
alkylating agent family used to treat a variety of cancers
Side effects: Ifosfamide not only attack
cells but also non malignant cells, which
often leads, in most patients, to the following side effects:
- mild nausea and
- Unusual tiredness or
doctor immediately if you experience any of these symptoms:
urination or red urine
bruising or bleeding
- signs of
infections: fever, chills, sore throat, rash, etc.
- agitation, confusion, or hallucinations.
1 - nlm.nih.gov, Ifosfamide: side effects
santecheznous.com, Comment doit-on employer ce
(how to use this medication?)