Brand name: Hydrea
Other names: Droxia, Mylocel
available by prescription only
Hydroxyurea is used to treat the following malignancies:
forms of skin
of the head and neck, excluding lips
forms of leukemia
cancer that has spread or returned after treatment; in short, all ovarian cancers that are not responded to
the standard therapy.
Hydroxyurea may also be prescribed to treat other medical conditions not mentioned in this article. Talk to your
doctor or pharmacist for more information on Hydroxyurea.
Hydroxyurea comes as in
capsule to be taken by mouth
Dosage: The dosage of Hydroxyurea recommended
by your oncologist varies depending on your condition, the type or severity of cancer, and your body surface
area (BSA). If you are taking other chemotherapy drugs, you can be recommended to take a lower
dosage. Hydroxyurea is usually taken once a day. If you receive
radiotherapy at the same time, Hydroxyurea should be taken at least seven days before the beginning of the
radiotherapy. In the absence of complications, you should continue taking the drug during and after the therapy.
You may experience side effects while taking Hydroxyurea, it is not a reason to discontinue the treatment;
contact your doctor before taking any decision.
Depending on the reaction of your body
or your health status, your oncologist may adjust the doses. If your doctor has recommended a dosage
different from the one indicated above, it is important to follow the directions exactly; do not change or
discontinue the therapy without first consulting your doctor; this can cause serious health problems.
way to take Hydroxyurea is to swallow it. If you cannot swallow the capsule, pour the contents into a glass of
water and drink it immediately. It is important not to inhale the powder. Avoid Hydroxyurea from coming into
contact with your skin or mucous membranes. If the powder is spilled, you must wipe it immediately.
Storage: store Hydroxyurea
at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Keep the medication out of the reach of children
. Hydroxyurea and all other drugs should not be used beyond the expiration date printed on the
Overdose: Hydroxyurea can cause a
life-threatening decrease in the number of blood cells in your body.
As with any drug, Hydroxyurea overdose may be dangerous, mainly if taken for long term. In fact, an overdose
of Hydroxyurea can lead to death in fragile patients. Contact your doctor or the poison control center nearest
you if you experience the following symptoms:
- shortness of
- unusual bleeding or
- Signs of infection:
fever, sore throat, chills, cough, etc.
take Hydroxyurea and
all medications as prescribed.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missing, it can be dangerous. Contact your doctor or wait to go back to
your regular schedule. This applies not only to Hydroxyurea
but also any other drug.
is contraindicated or should be used with precautions in the following conditions:
such as human immunodeficiency virus (HIV)
to Hydra or one of its ingredients.
Mechanism of action (MOA):
Hydroxyurea belongs to the class of chemotherapy drugs called antimetabolites. Normally, before a cell divides into
two, its DNA is copied and each daughter cell receives a copy. Hydroxyurea slows or stops growth of cancer cells by
interfering with their DNA material they need for reproduction.
talk you to your doctor
before prescription or non prescription medications including
vitamins and nutritional supplements.
Some medicines are not recommended to be taken with Hydroxyurea. Tell your doctor or pharmacist if you are taking
any of these medications:
- Interferons (Actimmune, Avonex, Betaseron, Rebif, etc.)
- Aids/HIV medications
such as didanosine (Videx) and stavudine (Zerit)
vaccines: BCG, yellow fever vaccine, etc..
- Ganciclovir, an antiviral drug
- Azathioprine, an immune system inhibitor
- Barbiturates, depressant drugs that causes relaxation and
, a drug
used to inhibit the production of
acid in the stomach
medication used to treat pain of
(Cytoxan, Cytoxan, Neosar, Procytox,
Revimmune), a drug used to treat several types of cancers
- All other chemotherapy
Side effects: Hydroxyurea not only
cells but also normal
(healthy) cells, which often leads to, in certain patients, the following side effects:
nausea and vomiting
purple, blue, or black discoloration on the nails.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
- fast or
irregular heart beat
to severe nausea or vomiting
of constriction of the throat
Swelling of feet or lower legs.