Generic name: Fulvestrant
available by prescription only
Indication: Fulvestrant is used to treat
hormone-dependent locally metastatic breast cancer in some postmenopausal women. Fulvestrant may also be used to
treat other types of breast cancers that have been unsuccessfully treated with antiestrogen medications such as
Fulvestrant may also be prescribed for
other medical conditions not mentioned in this article; talk to your doctor or pharmacist for more
Fulvestrant is taken as
an injection into the muscle (intramuscular).
Dosage: to determine an effective dosage to
cancer, your doctor will consider
your state of health, other medications you are taking, the severity of the tumor and your body surface area
(BSA). After the evaluation of these criteria, you will be recommended to take the most effective doses. It is
important to take Fulvestrant as recommended by your doctor. Even if you are experiencing side effects, it is
important to continue and complete the therapy as indicated by your doctor or pharmacist.
Fulvestrant is given intramuscularly
(injection into the muscle). Usually, the drug is given once per month in the muscle of the buttocks.
Fulvestrant may be injected by your health care provider or by yourself. If you take Fulvestrant by yourself,
you must learn how to do so if you are not a medical professional. It is necessary that you understand exactly
how to inject the drug as directed by your health care provider.
taking the medication, make sure it is in good quality. Fulvestrant solution comes as a thick, transparent,
colorless or turning yellow substance. Before injecting it, check whether it retains its color. Regardless the
circumstances, do not use the drug if it is cloudy or discolored. In addition, avoid using Fulvestrant if you
realize there particles floating in the content.
Storage: store Fulvestrant at room temperature
(15-25 ° C), away from light, moisture and heat above 40 ° C. Fulvestrant and all other medications should not
be used beyond the expiration date printed on the container. Keep the medication out of the reach of children.
Overdose: high or/and long term Fulvestrant
overdose can be dangerous. In fact, even at normal dose, Fulvestrant can lead to a decrease in white blood cells
or in platelets that can cause serious infections. If you take an overdose, contact your doctor or poison
control center nearest you to reduce or prevent complications. All chemotherapy drugs can lead to death when
they are overdosed.
it is important to
your best to take the medication as recommended by your doctor or pharmacist; and this is important not only
for Fulvestrant but
all other drugs
. Fulvestrant is taken
once a month; chance of missing dose is very low.
contraindicated or should be used with precaution in the following conditions:
to Fulvestrant or to any of its ingredients
- women who are
beginning a Fulvestrant treatment, talk to your doctor if you have chronic kidney disease, hemorrhagic disease,
thrombocytopenia, osteoporosis and epilepsy. In addition, let your
doctor know if you are being treated with anticoagulants.
Mechanism of action (MOA): Fulvestrant
belongs to estrogen
receptor antagonists, a group of chemotherapy drugs that inhibit and combat the development of
The fact that the cells of hormone-dependent breast cancers need estrogen for their growth and survival,
Fulvestrant works by blocking the effects of the hormone estrogen in the body.
Fulvestrant, tell your doctor about all medications you are taking, whether prescription or non prescription.
Talk to your doctor before taking vitamins and nutritional supplements. Some drugs such as anticoagulants
(blood thinners) and warfarin (Coumadin) can cause health problems when they are combined with Fulvestrant.
Fulvestrant may cause adverse effects in some patients; most Fulvestrant side effects include:
or decreased sexual desire
or tenderness of breasts
of fullness in abdomen
symptoms: runny nose, headache, muscle or joint pain, fatigue, sore throat, etc.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
of breath or difficulty breathing
- pain or
tenderness in the stomach
bleeding or bruising
of the skin or eyes
hoarseness or cough
tightness or wheezing
containing blood or blackish stools
- pain in
lower back or side
tingling, pain or weakness in hands, arms, legs or feet
of face, fingers, feet or lower legs
lips, fingernails, or palms Hand
or dark urine.