Fluorouracil Injection (Adrucil,
Brand name: Adrucil®
Other names: 5-FU
Fluorouracil is available by prescription only
Fluorouracil in used to treat the following cancer:
Fluorouracil can be used to treat
other medical conditions that are not mentioned in this article. Talk to your doctor or pharmacist for more
detail on Fluorouracil.
given by injection into a vein
your oncologist will
consider your health in general, other medications you are taking, type of cancer you have, and specially
your body surface area (BSA). The
recommended dose of fluorouracil varies greatly according to these criteria and the response of your body to
Fluorouracil is given once a day for 5
consecutive days; the therapy is repeated every 28 days. In
general, fluorouracil is administered as an intravenous injection (into a vein). The injection is done in a
hospital or a medical center. The medication must be prepared and administered by specialists in oncology or
hematology. Even in absence of serious side effects, a special monitoring during treatment is necessary.
cases, your doctor may indicate another dosage, depending on your medication condition or your body's response
to the drug. Whatever dosage prescribed, it is important to follow and complete the treatment as recommended by
your doctor. Misusing fluorouracil can lead to serious health problems.
the fact that
fluorouracil is administered in hospital by professionals, the risk of overdose is very low; however,
accidental overdose or administrative mistake can happen. An overdose of fluorouracil may cause severe and
even fatal health problems. There is no specific treatment for fluorouracil overdose; treatment is
Missing dose: It is basically difficult to miss a
dose if you keep all your doctor’s appointments. Do not neglect your appointment; one missed session or dose of fluorouracil can affect the entire
treatment. If for some reason you cannot be present at the hospital for the therapy, contact your health care
provider. Do not stay home because you are experience side effects.
: if you fall in any of the
categories below, f
luorouracil may not be an option for your medical condition:
allergic to fluorouracil or any of its ingredients
who are pregnant/breastfeeding
having potentially serious infection
suffering from malnutrition
having a decrease in the function of bone marrow.
Mechanism of action (MOA): Antimetabolites are chemical very
similar to normal substances within your cells; they have, however, property to interfere with DNA
production. When used as chemotherapy for cancer, they slow or stop
cancer cells and other cells that divide rapidly.
talk you to your doctor
vitamins or nutritional supplements.
Some medicines may affect the therapeutic effects of fluorouracil, or increase the risk of developing side effects.
Consult your doctor before taking the following medicines:
- Azathioprine, an immune system inhibitor
depressant drug that causes relaxation
, a drug
used to inhibit the
production of acid in the stomach
medication used to treat pain of gouty arthritis
vaccine, yellow fever vaccine, etc.
(Cytoxan, Cytoxan, Neosar, Procytox,
Revimmune), a drug used to treat several types of cancers
- Celecoxib, a non-steroidal anti-inflammatory drug (NSAID)
used in the treatment of osteoarthritis, rheumatoid arthritis, painful menstruation, colon and rectum
Side effects: while attacking
fluorouracil also affects
normal (healthy) cells, which lead to, in certain patients, the following side effects:
or darkening of the skin or nails
of skin to sunlight
in the hands or feet.
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
red skin rash
urination or red urine
bruising or bleeding
of the feet or legs
of the skin or eyes