Brand Name: Erbitux®
Other names: C225
Manufacturer / Distributor:
Erbitux is available by
Erbitux is given by
injection into a vein
Erbitux is used to treat colorectal
cancer, particularly in patients
who have not responded to other chemotherapy drugs. Erbitux can be used alone or in combination with Irinotecan,
another chemotherapy drug that blocks the action of topoisomerase I, an enzyme that cells need to
divide/multiply. Erbitux can also be used in combination with
in the treatment of neck and head cancers.
is sometimes used to treat other medical conditions that are mentioned in this article; talk to your physician
or pharmacist for more information on Erbitux.
Dosage: usually, Erbitux is given by injection
into a vein, once a week. The injection usually lasts for about two hours.
However, your oncologist can change the dosage, and recommend you to take the medication on a regular basis.
Erbitux can be taken in combination with irinotecan,
therapy or alone. Your oncologist will consider several criteria (your age, health, weight /
height) to determine the most appropriate and effective dosage for your condition. The dosage given is usually
determined depending on your body surface area (BSA), medical conditions and also the response of your body to
case, you should not deflect the instructions recommended by your doctor. During the treatment and even after,
it is important to drink plenty of water and other fluids to avoid damage to your kidneys, stomach and even your
Overdose: the fact that Erbitux is given in
hospital by health professionals, the risk of overdose is virtually nonexistent; The maximum single dose of
Erbitux administered to a patient is 1000mg, and no adverse effects is reported. However, In case you are
experience symptoms of overdose – severe headache, heart failure or other signs - contact your doctor
Erbitux is administered in hospital; therefore, it is very important to be present at each appointment to take the
medication as prescribed. If for some reasons you cannot be present, contact your oncologist before the date of the
appointment. As all chemotherapy drugs, misusing Erbitux can be fatal.
Erbitux is contraindicated or should be used with precaution in the following conditions:
to Erbitux or any of its ingredients
alteration of general condition.
Mechanism of action (MOA): t
he cells receive hormonal signals that cause them to multiply and then die (natural death of cells). Among the
agents in your body that involve in these processes include the epidermal growth factor receptor (EGFR). EGFR is a
particular type of protein that exists on the cell surface, which transmits growth signals to the inside of the
cell. ; EGFR is found on the surface of both cancerous and non cancerous cells.
cells live by diving anarchically. Erbitux works by binding to EGFR on the surface of
cells, preventing them to receive the signals necessary to multiply.
Before beginning the
treatment, tell your doctor about all medications you are taking, whether prescription or non prescription.
Talk to your doctor before taking vitamins, nutritional supplements and st john worth. Consult with your
doctor before taking these drugs:
- Ganciclovir, an antiviral drug
- Azathioprine, an immune system inhibitor
- Barbiturates, depressant drug that causes relaxation and
, a drug
used to inhibit the production of
acid in the stomach
medication used to treat pain of
vaccine, yellow fever vaccine, etc.
(Cytoxan), a medication of the
alkylating agent family used to treat a variety of cancers
(Cytoxan, Cytoxan, Neosar, Procytox,
Revimmune), a drug used to treat several types of cancers
- Celecoxib, a non-steroidal anti-inflammatory drug (NSAID)
used in the treatment of osteoarthritis, rheumatoid arthritis, painful menstruation, colon and rectum
Erbitux can cause adverse effects in some patients. Most common Erbitux side effects
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
disease such as formation of blood clots in the lungs
attack or fast heart beat
up blood or dry cough
of the hands that you cannot control
tightening of the hands or feet
throat or difficulty swallowing
- pain or
burning sensation in eye(s)
(which can be indicated by sore throat, fever, chills).
1 - pharmacyescrow.com
3 - nlm.nih.gov