names: Eligard TM,
Lupron®, Lupron Depot®, ViadurTM
Other names: Leuprorelin Acetate
agonist (hormone therapy)
Eligard is available by
form: Eligard is given by subcutaneous
(under the skin) injection
Eligard is used to treat the following medical conditions:
- Benign prostatic hypertrophy [(BPH), a non cancerous prostate disease].
can also be used to treat other medical conditions that are not mentioned in this article; talk to your doctor
or pharmacist for more information.
to prescribe you an
appropriate dosage, your oncologist will consider your health in general, other drugs you are taking, the
characteristic of the cancer (aggressive or not), and especially your body surface area (BSA). Recommended doses of Eligard vary greatly
depending to these criteria and the response of your body to the drug.
general, Eligard is given by injection under the skin. You may be recommended to take the drug once a month or
once of every 3, 4 or 6 months. In some cases, your doctor may indicate another dosage. Whatever the dosage
prescribed, it is important to follow and complete the treatment as recommended by your doctor. It is also
necessary to respect the time interval required between the doses. If for some unavoidable reasons you cannot
take the medication at the appointed time, call your doctor as soon as you can. However, the best thing is to
take Eligard as prescribed.
Your oncologist may do an implant under your
skin to inject the drug. If so, keep the area where you received the implant clean and dry for 24 hours; therefore,
swimming and/or bathing is not recommended during 24 hours after an Eligard injection. You may also need to cover
the area with a bandage until the wound heals.
The vials or kits of
Eligard should be refrigerated at a temperature between 2 ° C and 8 ° C, and protected from light. Do not let
the drug at the children reach. After opening, powder and solvent for the solution must be reconstituted and
administered immediately. The physicochemical stability of the reconstituted solution last about 30 minutes
at 25 ° C.
Eligard overdose is very rare, in fact, no cases of misuse or overdose has been
reported in clinical practice. However, if overdose occurs, medical attention is very important. In some
cases, symptomatic treatment can be recommended.
for some reasons you missed/forgot a dose or cannot be present at the hospital for the treatment, contact your
oncologist before the date of the appointment. In fact, this case is rarely reported.
Eligard is contraindicated, or should be used with precaution in the following
to Eligard or any of its ingredients
to other GnRH agonists
having a history of orchiectomy, removal of one or the two testicles
monochemotherapy for patients with
cancer associated with bone metastases or spinal cord compression.
Mechanism of action (MOA): Your body produces a group of cells
called gonadotropes. Located in the pituitary glands
(hypophysis), those cells produce the gonadotropins
follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are controlled by
gonadotropin-releasing hormone (GnRH), another hormone produced and controlled by the hypothalamus. Certain
cancer cells such as those of prostate and breast cancers need those hormones to survive. Eligard works by
inhibiting the secretion of gonadotropes.
harmacokinetic studies of drug interactions with Eligard have been shown. However, for preventive measures, before
starting a treatment with Eligard, tell your doctor about all prescription and nonprescription medications you are
taking; the list include but not limited to aspirin, vitamins supplements, and the following dugs:
(Neoral, Restasis, Sandimmune)
Side effects: attacking
cells,Eligard also affects
normal (healthy) cells, which lead to, in certain patients, the following side
- bowel disorder
(diarrhea or constipation)
- anxiety or
- memory and
or darkening of the skin or nails
of skin to sunlight
in the hands or feet
- increased need to
urinate, especially at night
- breast tenderness or
change in breast size (both men and women)
- incapacity or decrease
in sexual desire in men and women
- decrease in size of
- vaginal discharge,
dryness, or itching (women)
- absence of menstrual
- Firmness or hardness
at subcutaneous injection spot.
If the side
effects above become severe or persist for weeks, contact your oncologist. In addition, contact your doctor
immediately if you experience any of these symptoms:
- testicular or
- inability to move arms
- painful or difficult
urination or red urine
bruising or bleeding
of the feet or legs
- numbness, tingling,
weakness, or pain in the feet or lower legs
of the skin or eyes.
1 - vidalpro.net, ELIGARD® 45 mg –
4 - Ganong, William F.: "Review of Medical Physiology", page 248. Lange,