Efudex (Fluorouracil topical, Carac, Fluoroplex, 5-fluorouracil, 5-FU)
Brand name: Efudex, Carac,
Other names: 5-fluorouracil, 5-FU
Availability: Efudex is available by prescription
Efudex comes as a
solution and cream to apply to the skin
Efudex is used to treat certain skin affections such as:
cancer of the skin
keratosis, a skin condition that can lead to skin cancer
can be used to treat other medical conditions that are not mentioned in this article; talk to your doctor or
pharmacist for more details on Efudex.
Dosage: Apply Efudex to the affected area of
your skin using a non-metal applicator or by wearing a glove. The entire affected area of the skin must be
covered with the cream. The medication must be applied twice daily after washing/cleaning the diseased skin.
After the application, wash your hands thoroughly with soap and water. Avoid the cream in contact with your
eyes, eyelids, the corners of nostrils, mouth, easily irritated areas such as genitals. If the lesion is closed
to your eyes, nose or mouth, you must carefully apply the medication to avoid penetration of the drug in these
people, Efudex can cause inflammation and irritation of the skin. If this is your case and the inflammation is
not too severe, do not discontinue the treatment; complete the therapy as recommended by your doctor. A
treatment with Efudex usually last 2 to 4 weeks.
doctor will base on your weight, health, and the severity/extent of the tumor to prescribe you an appropriate
dose of Efudex. If you are taking other chemotherapy drugs, you may receive lower disease. Whatever the dosage
recommended, it is important that you adhere to it. Misusing Efudex
can reduce its healing power.
Overdose: since it is a tropical treatment, the
risk of overdose is almost inexistent. However, Efudex may cause irritation and/or inflammation even at normal.
If irritation is such that you cannot continue the treatment, contact your health care provider before taking
It is important that
you use Efudex exactly as indicated by your physician or pharmacist; in case you forgot to apply the
medication, apply the missed dose as soon as you remember it; if it is almost time for the next dose, skip
the missed dose and continue your regular dosing. Double dose is not recommended.
Store Efudex at room temperature and out of reach of children. The drug should not be kept in the light or
moisture. After use, do not throw the container in the garbage. For more information on proper disposal of Efudex,
talk to your physician or pharmacist.
While you are treated with
Efudex, you need to take the following precautions:
avoid the treated area to prolonged sun exposure
tell your doctor if you have a history of other skin problems or acne rosacea
Tell your physician if you are taking prescription or nonprescription medications including aspiring,
vitamins and nutritional supplements.
Mechanism of action (MOA): Efudex acts by inhibiting DNA
synthesis and thus slows or stops the division of
Efudex is contraindicated or should be used with precaution in the following conditions:
to fluorouracil or any of its components
can be applied to the skin of infants and children, but under the strict supervision of a
Side effects: in some patients, Efudex can
cause skin reactions. Common Efudex side effects include:
If the side
effects above persist for days or weeks, contact your oncologist. In addition, contact your doctor immediately
if you experience any of these symptoms:
red skin rash