Brand name: Sprycel®
Manufacturer / Distributor:
Sprycel is available by
U.S. Food and Drug Administration (FDA) approved SPRYCEL® (dasatinib) in
2006 for the treatment of certain types of cancers (see indications)
is used to treat the following cancerous conditions:
in case of resistance or intolerance to prior therapy;
chromosome-positive acute lymphoblastic leukemia (Ph + ALL) in adults, in case of resistance or intolerance
to prior therapy.
is sometimes used to treat other medical conditions not mentioned in this article; talk to your physician or
pharmacist for more information.
Dasatinib is available
in tablet form to be taken by mouth
Dosage: to choose the most effective dosage to
combat the disease, your physician will rely on several factors: age, health status, body surface area (BSA), type and severity of the
cancer. Usually, lower doses are
given to patients that are taking other drugs. Misusing Dasatinib can cause serious health problems; it should
be prescribed by an oncologist or physician trained or experienced in the use of chemotherapy
drugs. Do not change or stop taking the medication even if you
experience side effects; chemotherapy drugs – including Dasatinib - cause side effects in most
Dasatinib is taken 2 times daily, 1 tablet in the morning and 1 tablet in the evening, with or without food. It
is better to take the medicine around the same times every day. DASATINIB should be swallow whole, do not chew
or crush the tablet. In addition, avoid drinking grapefruit juice or eating foods rich in fat during the
Dasatinib exactly as directed by your doctor is very important. If for valid reasons (such as development of
major complications) you cannot continue the therapy, contact your physician immediately; do not discontinue the
treatment without first contacting your doctor.
Storage: keep Dasatinib tightly closed in the
container it came, out of the reach of
Dasatinib at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Dasatinib and all other
medications should not be used beyond the expiration date printed on the container.
Overdose: any chemotherapy drug
overdose can be fatal. The risk of complication is even higher
when the drug is overdosed for a long term. In fact, overdosing of certain chemotherapy drugs, including
Dasatinib, can lead to
death. Even in the absence of overdose,
Dasatinib can damage
the bone marrow. It is extremely important that you take the
medication as indicated by your health care provider or according to the directions on the label.
do your best to take
the medication around the same time every day.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one. Contact your doctor or wait to go back to your regular
is contraindicated in case of:
to the drug or any of the constituents
Mechanism of action (MOA): Dasatinib is a protein-tyrosine kinase
inhibitor. That is, it works by blocking the protein kinases, proteins that are located within the leukemic
cells, and are responsible for their uncontrolled proliferation.
Interactions: if you are taking Dasatinib, it is better to talk to your doctor before taking
vitamins, nutritional supplements, or St. John's wort. Certain substances can
interact with Dasatinib, et cause health problems. Common drugs that tend to produce interaction with
- doxorubicin (Doxil)
- erythromycin (Erythrocin)
- indinavir (Crixivan)
- fentanyl (Duragesic,
- nelfinavir (Viracept)
- procainamide (Procanbid,
- atazanavir (Reyataz)
In addition to attacking
cells, Dasatinib may interfere with certain normal cells, and lead to the development of side effects in some
patients; most common Dasatinib side effects include:
pain or pain in your hands or the feet
sores or swelling and pain inside your mouth
pain or swelling.
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
- signs of
infections: fever, sore throat, chills,...
of the eyes, hands, arms, feet, ankles or lower legs
of breath or difficulty breathing
up bloody mucus
chest pain or chest pressure
- rapid or
bruising or bleeding
and tarry stools
- blood in
stools or urine
- slow or
or numbness of an arm or leg.