Brand name: Cytoxan®, Neosar®
Other names: CTX
Manufacturer / Distributor:
is available by prescription only
Cytoxan can be taken by
mouth in tablet form or by injection into a vein
Cytoxan is used in the treatment of a variety of cancers; mainly:
Hodgkin’s lymphomas and
chronic lymphocytic leukemia (CLL),
chronic myelocytic leukemia (CML), acute myelocytic leukemia (AML), acute lymphocytic leukemia
is sometimes used to treat non cancerous medical conditions; talk to
your physician or pharmacist to have more information on Cytoxan
The recommended dose of Cytoxan varies deepening the type of cancer being treated. Your age and body surface area
(BSA) play a major role in the dosage. If you are treated with other chemotherapy medications, you will likely
receive a lower dose of Cytoxan. In general, Cytoxan is taken by infusion into a vein or by mouth in tablet form.
Your doctor will prescribe you the method most appropriate to your condition.
doctor thinks it will be better that you take the drug in tablet form, you will be recommended to take the
medication every day in small doses. In some cases, Cytoxan can be taken in large doses for a few days at a
time, at intervals of two to four weeks between doses. If the intravenous form is chosen, the medication will be
administered twice a week or larger doses every three or four weeks, depending on your health and condition
the injection of Cytoxan is done in a hospital or a center equipped for its preparation. The drug must be
prepared and administered by specialists in oncology or hematology, or nurses who have experience in
administering chemotherapy drugs.
important that you drink plenty of fluids during the treatment. Drink at least 8 ounce glasses of fluid every
day to help you urinate frequently; this prevents the drug from damaging your kidneys and other organs in your
Keep Cytoxan out of
children reach. Store the medication at room temperature below 25 degrees Celsius (77 degrees Fahrenheit), and
strictly away from temperatures exceeding 30 degrees Celsius. Always store Cytoxan away from moisture and heat. Discard any unused doses after the expiration date. Talk
to your pharmacist about the proper disposal of the medication.
Cytoxan is given in hospital by professionals, the risk of overdose is virtually nonexistent. When the drug is
taken by mouth chance of overdose increases; either voluntary or involuntary, it may happen that some patients take
higher dose. Cytoxan overdose can cause severe and even fatal health problems. An accidental overdose in elderly
and especially among young children can lead to death.
If you think you have taken an overdose of Cytoxan, contact a poison control center or go to an emergency as soon
When Cytoxan is given by injection, it is administered in hospital; missing dose is very difficult. If for some
reasons you cannot be present at the hospital for the treatment, contact your health care provider before the
appointment. If you are recommended to take Cytoxan by mouth in tablet form, you can easily forget to take it. If
you forgot to take the drug for less than 12 hours, take the usual dose. Beyond 12 hours, it is better to wait for
the next dose to continue taking the medication as usual; do not double.
is contraindicated or should be used with precaution in the following conditions:
to cyclophosphamide or any of its ingredients
white blood cell count
Mechanism of action (MOA):
Cytoxan is an immunosuppressant; it slows or stops the growth of cancer cells in your body by attacking the genetic
material (DNA) they need to multiply.
Cytoxan should be taken exactly as recommended by your doctor or pharmacist. Cytoxan is often recommended to be
taken in the morning to reduce the risk of bladder disorder. In addition, avoid taking the drug with food; it can
cause stomach upset.
interact with certain substances; talk to your doctor before taking these products:
In addition to attacking
cells, Cytoxan can also affect normal cells, which can cause various adverse effects in some patients. Some
Cytoxan side effects include:
If the side
effects above become severe or persist for long, contact your oncologist. In addition, contact your doctor
immediately if you experience any of these symptoms:
constipation or diarrhea
of breath or difficulty breathing
bruising or bleeding
of the feet or ankles
or red urine.