Trade name: Leukeran
available by prescription only
Chlorambucil comes in
coated tablet form to be taken by mouth
Chlorambucil is used in
the treatment of many cancers, principally:
- Hodgkin's disease
- breast cancer
- testicular cancer
- chronic lymphocytic leukemia
- choriocarcinoma, an aggressive
form of cancer that occurs in a woman's uterus
- Thrombocythemia, a blood disorder
in which the body produces too many platelets (thrombocytes).
Chlorambucil may be used to treat
other medical conditions not listed in this article; talk to your doctor or pharmacist for more information.
Storage: Keep Chlorambucil tightly closed and
out of reach of children. Keep the medication in a dry place at room temperature and away from excess heat and
humidity. It is not recommended to keep Chlorambucil in the bathroom. For more information, talk to your
physician or pharmacist.
Dosage: Your oncologist will base on many
criteria to prescribe you an appropriate dosage: your weight, health in general, taking other drugs, and more
specifically the type of cancer you have. For example, if you have chronic lymphocytic leukemia, your doctor can
recommend you to take 0.15 mg chlorambucil per kilogram of body weight per day for four to eight weeks. Usually,
the drug is recommended to be taken 1 hour before or 2 hours after meal. In some cases, Chlorambucil can be
taken in combination with other anticancer drugs to increase the chances of surviving.
Depending on your condition or the
reaction of your body to the medication, your oncologist can adjust the dosage. Whatever the dose recommended,
it is important to take Chlorambucil as indicated. In the absence of complications, treatment should be
continued to the end.
important to drink plenty of fluids while taking chlorambucil to help your body rid itself of the toxic effects
of the drug. Drinking abundantly distilled water and fresh juice helps prevent kidney problems and other adverse
effects of Chlorambucil.
Overdose: It is very important to avoid
Chlorambucil overdose. As all chemotherapy drugs, chlorambucil can cause serious health problems including the
development of other types of cancers. If you think you have taken an overdose of the drug, you should
immediately contact your doctor or the poison control center nearest you. A health care provider can give you an
antidote, symptomatic treatment or blood transfusion to slow or stop the toxic effects of the
Missing dose: Chlorambucil can be taken one or
several times per day. If you have been recommended to take the drug once a day and you miss a dose until the
next day, do not double the dose.
If you have been recommended to take medication several times a day and forgotten until the next dose, skip the
missed dose; do not double the dose. Don’t ever take less or more of the prescribed dose.
Chlorambucil should not be given to patients who have or fall into any of these categories:
who are breastfeeding
disorders: bleeding disorders,
platelet disorders, hemophilia and anemia
or ongoing radiation therapy
viral infections: chickenpox, cold sores, herpes, etc.
or allergic reaction to Chlorambucil or any of its components.
Mechanism of action (MOA): Chlorambucil acts by modifying the
structure of the constituents of the cancer cells (DNA), thus slowing or stopping their
certain drugs may
interact with Chlorambucil; do not take prescription or non-prescription medications along with Chlorambucil
without first contacting your health care provider. the following medications can interact with
acid, an antibiotic indicated for the treatment of gram-positive UTI
an immunosuppressive agent
medications that increase blood cells levels: filgrastim, pegfilgrastim,
talk to your doctor before taking any of the following :
- St. John
In addition to causing death of cancer cells, Chlorambucil tends to interfere with healthy
cells that multiply quickly, and cause adverse effects; the most common chlorambucil side effects of
- hair loss
- dry skin
- constipation or
- skin disorders:
changes or metallic food taste.
cause serious side effects which require immediate medical attention; contact your doctor immediately if you
experience any of these symptoms:
- shortness of breath
(temporary loss of
bruising or bleeding
which can be indicated by fever or sore throat.
useful tips :
The chance to not suffer side effects of chemotherapy is very minimal. Whether you are male or female, you have an
increased to experience side effects during and after chemotherapy: skin problems, nausea, intestinal problems,
vomiting, loss of appetite, extreme fatigue, impotence, etc. However, there are steps you can take to eliminate or
reduce these effects and improve the quality of your life. During and after chemotherapy, you can practice these
a good nutrition
- do not
plenty of cool water; this helps to prevent dry mouth and kidney problems
if necessary, take a nap in the afternoon; it helps prevent fatigue and immune
sugar free chewing gun to keep your lips hydrated and your breath fresh
- if you
have pain, redness or swelling at the injection site, apply ice to it, and notify your physician
reduce or prevent nausea and vomiting, drink iced tea or ginger tea; this practice can restore your stomach
to normal functioning
plenty of fresh fruit especially strawberries, grapes, cantaloupe, apple, ...
fried and fatty foods; highly scented is also contraindicated
- If you
feel down, try to distract yourself: watch / listen to a funny broadcast radio or television. You can also
have a conversation with someone that can make you laugh.