Brand Name: Erbitux®
Other names: C225
Cetuximab is available by prescription only
form: Cetuximab is given by injection into a
Cetuximab is used to treat colorectal cancer, particularly in patients who have not responded to other
chemotherapy drugs. Cetuximab can be used alone or in combination with Irinotecan, another chemotherapy drug
that blocks the action of topoisomerase I, an enzyme that cells need to divide/multiply. Cetuximab can also be
used in combination with radiotherapy in the treatment of neck and head cancers.
Cetuximab is sometimes used to treat
other medical conditions that are mentioned in this article; talk to your physician or pharmacist for more
information on Cetuximab.
usually, Cetuximab is given by injection into a vein, once a week. The injection usually lasts for about two
However, your oncologist can change the dosage, and recommend you to take the medication on a regular basis.
Cetuximab can be taken in combination with irinotecan, radiotherapy or alone. Your oncologist will consider several
criteria (your age, health, weight / height) to determine the most appropriate and effective dosage for your
condition. The dosage given is usually determined depending on your body surface area (BSA), medical conditions and
also the response of your body therapy.
case, you should not deflect the instructions recommended by your doctor. During the treatment and even after,
it is important to drink plenty of water and other fluids to avoid damage to your kidneys, stomach and even your
the fact that Cetuximab is given in hospital by health professionals,
the risk of overdose is virtually nonexistent; The maximum single dose of Cetuximab administered to a patient is 1000mg, and no adverse effects is reported. However,
In case you are experience symptoms of overdose – severe headache, heart failure or other signs - contact your
Cetuximab is administered in hospital; therefore, it is very important to be present at each appointment to take
the medication as prescribed. If for some reasons you cannot be present, contact your oncologist before the date of
the appointment. As all chemotherapy drugs, misusing Cetuximab can be fatal.
: Cetuximab is contraindicated or should be used with precaution in the following conditions:
to Cetuximab or any of its ingredients
alteration of general condition.
Mechanism of action (MOA): t
he cells receive hormonal signals that cause them to multiply and then die (natural death of cells). Among the
agents in your body that involve in these processes include the epidermal growth factor receptor (EGFR). EGFR is a
particular type of protein that exists on the cell surface, which transmits growth signals to the inside of the
cell. ; EGFR is found on the surface of both cancerous and non cancerous cells.
cells live by diving anarchically. Cetuximab works by binding to EGFR on the surface of cancer cells, preventing
them to receive the signals necessary to multiply.
Before beginning the treatment, tell your doctor about all medications you are taking, whether prescription or non
prescription. Talk to your doctor before taking vitamins, nutritional supplements and st john worth. Consult with
your doctor before taking these drugs:
- Ganciclovir, an antiviral drug
- Azathioprine, an immune system inhibitor
depressant drug that causes relaxation and sleepiness
, a drug used to inhibit the
production of acid in the stomach
, a medication used to treat pain of gouty arthritis
vaccine, yellow fever vaccine, etc.
(Cytoxan), a medication of the alkylating agent family used to treat a variety of cancers
(Cytoxan, Cytoxan, Neosar, Procytox, Revimmune), a drug used to treat several types of cancerss
- Celecoxib, a non-steroidal anti-inflammatory drug (NSAID)
used in the treatment of osteoarthritis, rheumatoid arthritis, painful menstruation, colon and rectum
Cetuximab can cause adverse effects in some patients. Most common Cetuximab side effects include:
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
disease such as formation of blood clots in the lungs
attack or fast heart beat
up blood or dry cough
of the hands that you cannot control
tightening of the hands or feet
throat or difficulty swallowing
- Pain or
burning sensation in eye(s)
(which can be indicated by sore throat, fever, chills).
1 - pharmacyescrow.com
Cetuximab .com, Cetuximab
3 - nlm.nih.gov.