Brand name: Camptosar
Other names: Camptothecin-11, CPT-11
alkaloid and topoisomerase I inhibitor
is available by
Camptosar is used in the treatment of advanced colorectal cancer. The drug can be taken alone or in combination with other
anti-cancer drugs such as 5-FU (fluorouracil).
prescribed for other medical conditions not mentioned in this article; talk to your doctor or pharmacist for more
form: Camptosar comes as a liquid to be
given intravenously into a vein
Camptosar is given by
intravenous injection over a period of about 90 minutes, usually in combination with other drugs. The usual
dose is either 180 mg/m2 (milligram per square meter) of body surface area (BSA), every two weeks in
polychemotherapy; or 350 mg/m2 in monochemotherapy every 3
weeks. However, in cases your body develops adverse reactions, the dosage can be reduced. Camptosar should be
administered by a specialist in oncology/hematology, or by competent nurse having experience in giving
Camptosar is administered in hospital by medical professionals, the risk of overdose is greatly reduced; however,
it can happen. Camptosar overdose often causes severe headache and
reinforces the toxic effects of the medication. If you suspect that you are suffering from an overdose, contact
your doctor immediately. There is no known antidote for Camptosar overdose; however, your physician can intervene
and prevent complications.
after receiving a
Camptosar injection, you may experience runny nose,
increased saliva, shrinking pupils, watery eyes, sweating, flushing, diarrhea or mild stomach cramps; this does not
mean you are overdosed. Most patients experience those side effects.
contraindicated or should be used with precaution in the following conditions:
to Camptosar or to one of its
number of white blood cells
(presence of bilirubin in the
to three times than normal
failure, kidney failure, or chronic lung disease.
Mechanism of Action (MOA):
Camptosar is an antineoplastic (anticancer) agent; it kills cancer cells by interfering with their genetic material
(DNA), which prevents them from reproducing or multiplying.
Talk you to your doctor
vitamins, nutritional supplements, or St. John's worth. In addition, it is important to tell your
oncologist before taking any of the following drugs: following medicines:
(Carbatrol, Epitol, Tegretol)
- Phenytoin (Dilantin,
Phenytek); rifabutin (Mycobutin)
Rifampin (Rifadin, Rimactane, in Rifamate and Rifater).
effects: by stopping
the growth of cancer cells, Camptosar also interfere with your healthy
cells that multiply quickly; this often cause adverse effects. Common Camptosar side effects
- Perte des cheveux
- nausea and
of sores in the mouth
disorders (constipation or diarrhea).
rare, Camptosar can cause
serious side effects which require immediate medical attention; contact your doctor immediately if you
experience any of these symptoms:
- shortness of breath or
- painful or difficulty
- yellowing of the skin
or eyes (jaundice)
- skin disorders such as
rash, hives or itching
- Swelling of your arms,
feet, ankles, or lower legs.