L-PAM, L-Sarcolysin, Phenylalanine
Alkeran can be taken by
intravenous injection (IV) and/or as tablets by mouth, on an empty stomach.
type: Alkeran is
classified as a nitrogen mustard alkylating agent
available by prescription only
Alkeran is used in the
Occasionally, Alkeran is used to treat the following cancers:
Note: your doctor can use the drug to
treat other medical conditions non-mentioned in this article if he believes it can be
ALKERAN is contraindicated
in the following conditions:
Alkeran or one of its components
not recommended while taking Alkeran
- using Alkeran
is not recommended during pregnancy, especially during the first quarter; the drug may cause problems
which can be harmful to the fetus
and children are treated with Alkeran under strict medical supervision.
have one of the following medical conditions, let it be known to your doctor before beginning an Alkeran
- glucose-galactose malabsorption
- You have
been treated with radiotherapy or antineoplastic agents during the previous 3 weeks.
Mechanism of Action (MOA)
- Alkeran destroys cancer
cells by forming cross-linkages between DNA strands (deoxyribonucleic acid), which thereby inhibiting the
replication of tumor cells.
: Alkeran may be toxic or cause serious infections when it is associated with nalidixic acid
, cyclosporine or other immunosuppressants. In addition, the association of high-dose Alkeran and cyclosporine is
toxic to the kidney.
: Alkeran attack not only cancer cells but healthy cells that multiply quickly, which often leads to adverse
effects. The most common Alkeran side effects include:
- loss of
- rash and
- increased risk of
- Pulmonary fibrosis
- Mouth blistering,
sometimes inflammation of the mouth.
doctor immediately if you experience any of the following symptoms:
black, tarry stools
urine or blood in
of the skin or eyes
- increased risk of infection
breathing or shortness of breath.